Use of Plasma Fragments of Propeptides of Type III, V, and VI Procollagen for the Detection of Liver Fibrosis in Type 2 Diabetes

Autor: Morten A. Karsdal, Diana Barb, Diana Julie Leeming, Jinping Lai, Kenneth Cusi, Fernando Bril, Srilaxmi Kalavalapalli, Matthew Rabe
Rok vydání: 2019
Předmět:
Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Biopsy
Endocrinology
Diabetes and Metabolism
030209 endocrinology & metabolism
Collagen Type VI
Type 2 diabetes
Sensitivity and Specificity
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
Predictive Value of Tests
Fibrosis
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Aspartate Aminotransferases
Longitudinal Studies
030212 general & internal medicine
Aged
Advanced and Specialized Nursing
Receiver operating characteristic
medicine.diagnostic_test
Platelet Count
business.industry
Type 2 Diabetes Mellitus
Alanine Transaminase
Middle Aged
medicine.disease
Peptide Fragments
Procollagen peptidase
Collagen Type III
Diabetes Mellitus
Type 2
Liver biopsy
Female
business
Collagen Type V
Biomarkers
Procollagen
Zdroj: Diabetes Care. 42:1348-1351
ISSN: 1935-5548
0149-5992
DOI: 10.2337/dc18-2578
Popis: OBJECTIVE This study assessed the utility of plasma fragments of propeptides of type III (PRO-C3), V (PRO-C5), and VI (PRO-C6) procollagen for the detection of liver fibrosis in patients with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS Patients with T2DM (n = 191) underwent an oral glucose tolerance test, a liver 1H-MRS, and a liver biopsy when indicated. PRO-C3, PRO-C5, and PRO-C6 were blindly assessed. RESULTS PRO-C3 performed well for the diagnosis of moderate-to-advanced (area under the receiver operating characteristic curve [AUROC] 0.81 [95% CI 0.74–0.88]) and advanced (AUROC 0.88 [0.80–0.95]) fibrosis in T2DM patients. Its performance was similar to that of AST to platelet ratio index (APRI) (AUROC 0.83 and 0.87, respectively) and Fibrosis-4 (FIB-4) (AUROCs 0.83 and 0.86, respectively) scores. Use of PRO-C5 and PRO-C6 did not improve the accuracy to detect liver fibrosis. After 18 months, PRO-C3 changes were associated with changes in fibrosis stages. CONCLUSIONS PRO-C3 performed well for the detection of fibrosis in T2DM patients and showed promising results for prediction of histological changes in fibrosis stage with treatment.
Databáze: OpenAIRE
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