Associating liver partition and portal vein ligation for staged hepatectomy versus sequential transarterial chemoembolization and portal vein embolization in staged hepatectomy for HBV-related hepatocellular carcinoma: a randomized comparative study

Autor:	Wan Yee Lau, Cheng-Jian He, Weiping Zhou, Yun Yang, Ye-Fa Yang, Ning-Yang Jia, Hui Liu, Gang Huang, Peng-Peng Li, Ze-Ya Pan
Rok vydání:	2022
Předmět:	medicine.medical_specialty business.industry Hepatocellular carcinoma medicine.medical_treatment Portal vein embolization medicine Original Article Portal vein ligation Hepatectomy medicine.disease business Surgery
Zdroj:	Hepatobiliary Surg Nutr
ISSN:	2304-389X 2304-3881
DOI:	10.21037/hbsn-20-264
Popis:	BACKGROUND: Both portal vein embolization (PVE) and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) have merits and demerits when used in patients with unresectable liver cancers due to insufficient volumes in future liver remnant (FLR). METHODS: This study was a single-center, prospective randomized comparative study. Patients with the diagnosis of hepatitis B related hepatocellular carcinoma (HCC) were randomly assigned in a 1:1 ratio to the 2 groups. The primary endpoints were tumor resection and three-year overall survival (OS) rates. RESULTS: Between November 2014 to June 2016, 76 patients with unresectable HBV-related HCC due to inadequate volume of FLR were randomly assigned to ALPPS groups (n=38) and TACE + PVE groups (n=38). Thirty-seven patients (97.4%) in the ALPPS group compared with 25 patients (65.8%) in the TACE + PVE group were able to undergo staged hepatectomy (risk ratio 1.48, 95% CI: 1.17–1.87, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5028c5d8d05fc4c66077b27ea4c683f2 https://doi.org/10.21037/hbsn-20-264 Zobrazit plný text záznamu