Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin–angiotensin system
| Autor: | Selin Yamakoğlu, Suleyman Gultepe, Müjdat Uysal, Vakur Olgaç, F. Ilkay Alp-Yıldırım, Seldag Bekpinar, Ezgi Cibali, Ece Karaca, B. Sönmez Uydeş-Doğan |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Endothelium Physiology medicine.medical_treatment Renal function 030204 cardiovascular system & hematology Resveratrol Pharmacology Kidney Renin-Angiotensin System 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) medicine.artery Renin–angiotensin system medicine Animals RNA Messenger Rats Wistar Aorta Dose-Response Relationship Drug business.industry Angiotensin II General Medicine Ciclosporin Rats Vasodilation 030104 developmental biology medicine.anatomical_structure Immunosuppressive drug Gene Expression Regulation chemistry Cytoprotection NADPH Oxidase 4 Vasoconstriction Cyclosporine business medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 97:1115-1123 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/cjpp-2018-0753 |
| Popis: | Cyclosporine, an immunosuppressive drug, exhibits a toxic effect on renal and vascular systems. The present study investigated whether resveratrol treatment alleviates renal and vascular injury induced by cyclosporine. Cyclosporine (25 mg/kg per day, s.c.) was given for 7 days to rats either alone or in combination with resveratrol (10 mg/kg per day, i.p.). Relaxation and contraction responses of aorta were examined. Serum levels of blood urea nitrogen, creatinine, angiotensin II, and angiotensin 1-7 were measured. Histopathological examinations as well as immunostaining for 4-hydroxynonenal and nitrotyrosine were performed in the kidney. RNA expressions of renin–angiotensin system components were also measured in renal and aortic tissues. Cyclosporine decreased the endothelium-dependent relaxation and increased vascular contraction in the aorta. It caused renal tubular degeneration and increased immunostaining for 4-hydroxynonenal, an oxidative stress marker. Cyclosporine also caused upregulations of the vasoconstrictive renin–angiotensin system components in renal (angiotensin-converting enzyme) and aortic (angiotensin II type 1 receptor) tissues. Resveratrol co-treatment prevented the cyclosporine-related deteriorations. Moreover, it induced the expressions of vasodilatory effective angiotensin-converting enzyme 2 and angiotensin II type 2 receptor in aorta and kidney, respectively. We conclude that resveratrol may be effective in preventing cyclosporine-induced renal tubular degeneration and vascular dysfunction at least in part by modulating the renin–angiotensin system. |
| Databáze: | OpenAIRE |
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