Distinct clinicopathological differences between early gastric cardiac and non-cardiac carcinomas: A single-center retrospective study of 329 radical resection cases

Autor: Yaohui Wang, Yi Fen Zhang, Li Li Gao, Xiu Qing Li, Qin Huang, Chen Xi Wang
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Perineural invasion
Single Center
Gastroenterology
Early gastric carcinoma
Heart Neoplasms
03 medical and health sciences
0302 clinical medicine
Papillary adenocarcinoma
Poorly cohesive carcinoma
Gastrectomy
Risk Factors
Stomach Neoplasms
Submucosa
Metaplasia
Internal medicine
medicine
Carcinoma
Humans
Neoplasm Invasiveness
lcsh:RC799-869
Aged
Retrospective Studies
Early gastric cardiac carcinoma
business.industry
digestive
oral
and skin physiology
General Medicine
Hepatology
medicine.disease
Oesophageal invasion
digestive system diseases
Lymphovascular
medicine.anatomical_structure
030220 oncology & carcinogenesis
Clinicopathologic features
lcsh:Diseases of the digestive system. Gastroenterology
030211 gastroenterology & hepatology
medicine.symptom
business
Research Article
Zdroj: BMC Gastroenterology, Vol 20, Iss 1, Pp 1-10 (2020)
BMC Gastroenterology
DOI: 10.1101/2020.04.04.20052852
Popis: Background Early gastric carcinoma is heterogeneous and can be divided into early gastric cardiac carcinoma (EGCC) and early gastric non-cardiac carcinoma (EGNCC) groups. At present, differences in clinicopathology remains obscure between EGCC and EGNCC fundus–corpus and antrum–angularis–pylorus subgroups, especially between EGCC with and without oesophageal invasion. Methods In this study, we studied 329 consecutive early gastric carcinoma radical gastrectomies with 70 EGCCs and 259 EGNCCs. Results Compared to the EGNCC antrum–angularis–pylorus (n = 181), but not fundus–corpus (n = 78), sub-group, EGCC showed significantly older age, lower prevalence of the grossly depressed pattern, better tumor differentiation, higher percentage of tubular/papillary adenocarcinoma, but lower frequency of mixed poorly cohesive carcinoma with tubular/papillary adenocarcinoma, and absence of lymph node metastasis (LNM) in tumors with invasion up to superficial submucosa (SM1). In contrast, pure poorly cohesive carcinoma was less frequently seen in EGCCs than in EGNCCs, but mixed poorly cohesive carcinoma with tubular/papillary adenocarcinomas was significantly more common in the EGNCC antrum–angularis–pylorus sub-group than in any other group. No significant differences were found between EGCC and EGNCC sub-groups in gender, tumor size, H. pylori infection rate, and lymphovascular/perineural invasion. EGCC with oesophageal invasion (n = 22), compared to EGCC without (n = 48), showed no significant differences in the H. pylori infection rate and oesophageal columnar, intestinal, or pancreatic metaplasia, except for a higher percentage of the former in size > 2 cm and tubular differentiation. Conclusions There exist distinct clinicopathologic differences between EGCC and EGNCC sub-groups; EGCC was indeed of gastric origin. Further investigations with larger samples are needed to validate these findings.
Databáze: OpenAIRE
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