Granule cell dispersion is not a predictor of surgical outcome in temporal lobe epilepsy with mesial temporal sclerosis
| Autor: | Ricardo Silva Centeno, Luís Otávio Sales Ferreira Caboclo, Anaclara Prada Jardim, Carla A. Scorza, Marinho Tf, Murilo Martinez Marinho, Carmen Lucia Penteado Lancellotti, Targas Yacubian Em, Esper A. Cavalheiro, Ana Paula Hamad, da Costa Neves Rs |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty medicine.medical_treatment macromolecular substances Hippocampal formation Pathology and Forensic Medicine Temporal lobe Epilepsy medicine Humans In patient Anterior temporal lobectomy Retrospective Studies Neurons Sclerosis business.industry Retrospective cohort study General Medicine medicine.disease Anterior Temporal Lobectomy Prognosis Granule cell dispersion Treatment Outcome Neurology Epilepsy Temporal Lobe Temporal sclerosis Female Neurology (clinical) business |
| Zdroj: | Clinical neuropathology. 32(1) |
| ISSN: | 0722-5091 |
| Popis: | The aim of this retrospective study of a series of patients with mesial temporal lobe epilepsy (MTLE) and mesial temporal sclerosis (MTS) was to analyze the association of granule cell dispersion (GCD) with surgical prognosis, patterns of MTS and clinical data. Hippocampal specimens from 66 patients with MTLE and unilateral MTS and from 13 controls were studied. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patients' clinical data, types of MTS and surgical outcome were reviewed. GCD occurred in 45.5% of cases and was not correlated with clinical variable. More severe neuronal loss was observed in patients with GCD. Except for MTS Type 2 - observed only in four no- GCD patients - groups did not differ with respect to the types of MTS. Surgical outcome was similar in both groups. In conclusion, GCD was associated with the degree of hippocampal cell loss, but was not a predictor of surgical outcome. |
| Databáze: | OpenAIRE |
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