The Role of ANK in Calcium Pyrophosphate Deposition Disease
| Autor: | Claudia M. Gohr, Brittany Bettendorf, Ann K. Rosenthal, Elizabeth Mitton-Fitzgerald |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Protein Conformation Chondrocalcinosis medicine.disease_cause Pyrophosphate Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Protein structure Rheumatology medicine Humans Phosphate Transport Proteins Gene 030203 arthritis & rheumatology Mutation business.industry Calcium pyrophosphate medicine.disease Transmembrane protein 030104 developmental biology chemistry Biochemistry business Function (biology) |
| Zdroj: | Current rheumatology reports. 18(5) |
| ISSN: | 1534-6307 |
| Popis: | The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. Much about the structure, function, and regulation of ANK remain unstudied. This review of the current literature examines recent contributions to our understanding of ANK. We focus on new work on the function, binding partners, and regulators of ANK. A more complete understanding of this important protein may help to identify future therapeutic targets for the treatment of calcium pyrophosphate deposition disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink