BAP-1 Expression Status by Immunohistochemistry in Cellular Blue Nevus and Blue Nevus-like Melanoma
| Autor: | Victor G. Prieto, Carlos A. Torres-Cabala, Nastaran Neishaboori, Phyu P. Aung, Jonathan L. Curry, Wen-Jen Hwu, Michael T. Tetzlaff, Priyadharsini Nagarajan, Doina Ivan, Wei Shen Chen, Pei Ling Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty animal structures Skin Neoplasms Adolescent Dermatology Common Blue Nevus complex mixtures Protein expression Pathology and Forensic Medicine Diagnosis Differential 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Blue Nevus-Like Melanoma Nevus Blue polycyclic compounds medicine Biomarkers Tumor Humans Child Blue nevus Melanoma In Situ Hybridization Fluorescence Malignant phenotype Chemistry Tumor Suppressor Proteins Cellular Blue Nevus Infant General Medicine Middle Aged Immunohistochemistry Child Preschool embryonic structures Female medicine.symptom Ubiquitin Thiolesterase |
| Zdroj: | The American Journal of dermatopathology. 42(5) |
| ISSN: | 1533-0311 |
| Popis: | The family of blue nevi includes the common blue nevus (BN), cellular blue nevus (CBN), and atypical BN, while melanomas with BN-like morphology can either arise in association with a blue nevus (MABN) or in the de novo setting mimicking cellular blue nevus (MMCBN). Recent molecular and immunohistochemical studies have demonstrated loss of BAP-1 in MABN/MMCBN but not in BN/CBN, suggesting that loss of BAP-1 correlates with a malignant phenotype in these lesions. In this study, we applied anti-BAP-1 antibodies to a series of CBN/BN (n = 11) and MABN/MMCBN (n = 4). Nuclear BAP-1 expression was detected in the majority of CBN/BN (n = 10/11) but was lost in 1 case. Most cases of MABN/MMCBN showed loss of nuclear BAP-1 expression (n = 3/4), with one case of MMCBN showing preserved BAP-1 expression. Demonstration of BAP-1 loss in a single case of CBN and preservation of BAP-1 expression in 1 case of MMCBN may indicate that detection of alterations in BAP-1 protein expression by immunohistochemistry may not be a completely reliable biomarker for the distinction of BN/CBN from MABN/MMCBN. Further investigation of the significance of BAP-1 loss/preservation in BN-like tumors is warranted. |
| Databáze: | OpenAIRE |
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