Higher total ghrelin levels are associated with higher insulin-mediated glucose disposal in non-diabetic maintenance hemodialysis patients
| Autor: | Maria Pia Mucci, Manuela Stulle, Gianfranco Guarnieri, Michela Zanetti, Gianni Biolo, A. Pirulli, Giovanni Panzetta, Rocco Barazzoni, A. Vasile, Franca Dore |
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| Přispěvatelé: | Barazzoni, Rocco, Zanetti, Michela, Stulle, M., Mucci, M. P., Pirulli, Alessia, Dore, Franca, Panzetta, G., Vasile, A., Biolo, Gianni, Guarnieri, Gianfranco |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Critical Care and Intensive Care Medicine Systemic inflammation insulin resistance inflammation ghrelin chronic kidney disease Insulin resistance Renal Dialysis Diabetes mellitus Internal medicine medicine Humans Insulin Resting energy expenditure Pancreatic hormone Aged Nutrition and Dietetics business.industry digestive oral and skin physiology Middle Aged Glucose clamp technique medicine.disease C-Reactive Protein Endocrinology Case-Control Studies Glucose Clamp Technique Linear Models Kidney Failure Chronic Female Ghrelin Basal Metabolism medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinical Nutrition. 27:142-149 |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2007.06.013 |
| Popis: | BACKGROUND & AIMS: Insulin resistance is common in maintenance hemodialysis (MHD) and it can contribute to exceedingly high mortality in MHD patients. Ghrelin is a gastric hormone whose total plasma concentration is increased in MHD. Emerging data suggest a potential role of ghrelin to modulate intermediate metabolism but the metabolic impact of ghrelin in chronic kidney disease is unknown. The current study aimed at assessing the potential relationships between ghrelin and insulin sensitivity in MHD. METHODS: Total (T-Ghr) and acylated (A-Ghr) ghrelin as well as insulin-mediated glucose disposal [(M): hyperinsulinemic-euglycemic clamp] were measured in non-diabetic non-obese ambulatory MHD patients (n=19, 16 Males). C-reactive protein (CRP) was also measured since systemic inflammation is associated with insulin resistance in non-renal patients and inflammation is negatively modulated by ghrelin in experimental models. RESULTS: Compared to control subjects (C: n=9, 7 Males), MHD had similar body fat and resting energy expenditure but reduced M and increased CRP (P |
| Databáze: | OpenAIRE |
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