Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer
| Autor: | Chandeene Roshanlall, Joe Carroll, John H. R. Winstanley, Angela Platt-Higgins, Lee Martin, Roger Barraclough, Suzete de Silva Rudland, Philip S. Rudland, Christopher R. West, Sam Leinster |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Cancer Research Pathology medicine.medical_specialty Adolescent Angiogenesis Sialoglycoproteins Breast Neoplasms Metastasis Breast cancer medicine Carcinoma Humans Neoplasm Invasiveness S100 Calcium-Binding Protein A4 Osteopontin Aged Aged 80 and over Neovascularization Pathologic biology business.industry S100 Proteins Estrogen Receptor alpha Cancer Middle Aged Prognosis medicine.disease Immunohistochemistry Survival Analysis Metastatic breast cancer Staining Survival Rate Oncology Multivariate Analysis biology.protein Regression Analysis Female business |
| Zdroj: | Clinical Cancer Research. 12:1192-1200 |
| ISSN: | 1557-3265 1078-0432 |
| DOI: | 10.1158/1078-0432.ccr-05-1580 |
| Popis: | PURPOSE: S100A4 and the estrogen-inducible osteopontin are alone capable of inducing angiogenesis and metastasis in rodent models for breast cancer. The present study assesses the relationship of S100A4 and osteopontin with vessel density and estrogen receptor alpha (ERalpha) in primary tumors and with survival of patients to ascertain their involvement in metastatic breast cancer. EXPERIMENTAL DESIGN: Primary tumors from 312 patients treated for minimally invasive human breast cancer were immunocytochemically stained and then assessed for the significance of their association with each other using Fisher's exact test or with patient survival over 18 years of follow-up using Kaplan-Meier plots and Wilcoxon-Gehan statistics. RESULTS: Antibodies to S100A4 significantly stained endothelial cells of vessels adjacent to S100A4-staining groups of carcinoma cells, and antibodies to osteopontin significantly stained groups of carcinoma cells staining for ERalpha (P < 0.0001). There was a significant association of tumors staining for S100A4 with those with high vessel density (P = 0.021) and of tumors staining for osteopontin with those staining for ERalpha (P = 0.034). The association of staining for S100A4, osteopontin, or vessel density with patient death was significant (P < 0.0001, P = 0.005, and P = 0.014, respectively). The difference in cumulative proportion surviving between S100A4-positive patients with higher or lower vessel density increased up to about 12 years, but thereafter decreased to virtually zero after 18 years of follow-up. Patients with both S100A4-positive and osteopontin-positive primary tumors showed a statistically significant reduction in survival time over those with either one alone (P < 0.019), although in multivariate regression analysis, only staining for S100A4 was significant (P < 0.001). CONCLUSIONS: It is suggested that in human breast cancer, S100A4 exerts some of its effects through angiogenesis, and that osteopontin is dependent on ERalpha for its expression. |
| Databáze: | OpenAIRE |
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