Hippocampal-Prefrontal Theta Transmission Regulates Avoidance Behavior
| Autor: | Rachel Mikofsky, Sofiya Hupalo, Sarah Canetta, Nancy Padilla-Coreano, Emily Alway, Richard Warren, Johannes Passecker, Mitchell P. Morton, David A. Kupferschmidt, Maxym Myroshnychenko, Joshua A. Gordon, Alvaro L. Garcia-Garcia, Christoph Kellendonk, Eric Teboul, Dakota R. Blackman, Kay M. Tye |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Theta activity Hippocampus Prefrontal Cortex Stimulation Hippocampal formation Biology Neurotransmission Optogenetics Synaptic Transmission Article 03 medical and health sciences Mice 0302 clinical medicine Avoidance Learning Animals Theta Rhythm Prefrontal cortex Maze Learning General Neuroscience Electrophysiological Phenomena 030104 developmental biology Transmission (telecommunications) nervous system Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron |
| ISSN: | 1097-4199 |
| Popis: | Long-range synchronization of neural oscillations correlates with distinct behaviors, yet its causal role remains unproven. In mice, tests of anxiety-like avoidance behavior evoke increases in theta-frequency (~8 Hz) oscillatory synchrony between the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). To test the causal role of this synchrony, we dynamically modulated vHPC-mPFC terminal activity using optogenetic stimulation. Oscillatory stimulation at 8 Hz maximally increased avoidance behavior compared to 2, 4 and 20 Hz. Moreover, avoidance behavior was selectively increased when 8 Hz stimulation was delivered in an oscillatory but not pulsatile manner. Furthermore, 8 Hz oscillatory stimulation enhanced vHPC-mPFC neurotransmission and entrained neural activity in the vHPC-mPFC network, resulting in increased synchrony between vHPC theta activity and mPFC spiking. These data suggest a privileged role for vHPC-mPFC theta-frequency communication in generating avoidance behavior, and provide direct evidence that synchronized oscillations play a role in facilitating neural transmission and behavior. |
| Databáze: | OpenAIRE |
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