Serum tryptophan decrease correlates with immune activation and impaired quality of life in colorectal cancer
| Autor: | David C. Henderson, Andy Huang, T G Allen-Mersh, C Glover, Dietmar Fuchs, Bernhard Widner |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
medicine.medical_specialty Colorectal cancer colorectal cancer Adenocarcinoma Gastroenterology immune activation Metastasis Clinical chemistry.chemical_compound Internal medicine medicine Humans Interleukin 6 Kynurenine Survival analysis Aged Rotterdam Symptom Checklist biology Interleukin-6 Rectal Neoplasms Tumor Necrosis Factor-alpha business.industry Liver Neoplasms Tryptophan Neopterin Middle Aged medicine.disease Survival Analysis Endocrinology quality of life Oncology chemistry Colonic Neoplasms biology.protein Regression Analysis Colorectal Neoplasms business Blood sampling |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6600336 |
| Popis: | Cancer-related indoleamine (2,3)-dioxygenase up-regulation by interferon-γ might influence quality of life by depleting serum tryptophan. We correlated serum tryptophan levels with immune activation and quality of life in patients with colorectal liver metastases. Venous blood was sampled from patients with primary colorectal cancer and from patients with metachronous colorectal liver metastases who completed quality of life and psychological questionnaires. Serum tryptophan, kynurenine, neopterin, interleukin 2 soluble receptor α (IL-2 sRα), soluble tumour necrosis factor receptor I (sTNF RI), interleukin 6, and C-reactive protein were measured. Liver metastasis volume was estimated by computerised tomography, and survival from blood sampling was noted. Sixty-six patients with colorectal cancer were studied (39 males; median age 66 years) of whom 25 had colorectal liver metastases only (17 males; median age 62 years; median liver metastasis volume 208 ml; median survival 234 days). Reduced serum tryptophan was significantly associated with Rotterdam Symptom Checklist physical symptom (r=−0.51, P=0.01) and Sickness Impact Profile (r=−0.42, P=0.04) scores, and correlated with increased serum neopterin (r=−0.36, P=0.003), IL-2 sRα (r=−0.51, P=0.01) and sTNF RI (r=−0.45, P=0.02) levels. Stepwise regression analyses suggested that serum tryptophan was an independent predictor of Rotterdam Symptom Checklist physical symptom (regression coefficient −20.78, P=0.01) and Sickness Impact Profile (regression coefficient −109.09, P=0.04) scores. The results supported a role for interferon-γ-mediated serum tryptophan decrease in cancer-induced quality of life deterioration. British Journal of Cancer (2002) 86, 1691–1696. doi:10.1038/sj.bjc.6600336 www.bjcancer.com © 2002 Cancer Research UK |
| Databáze: | OpenAIRE |
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