Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse .BETA. Cells
| Autor: | Misao Terada, Naoki Moritani, Tomoaki Nakada, Toru R. Saito, Haruo Hashimoto, Makoto Yokosuka, Wirasak Fungfuaug, Pudcharaporn Kromkhun |
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| Rok vydání: | 2010 |
| Předmět: |
Pancreas
Artificial medicine.medical_specialty endocrine system diseases Ovariectomy medicine.medical_treatment Posture Transplantation Heterologous Islets of Langerhans Transplantation Proceptive phase General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Mice Sexual Behavior Animal Insulin-Secreting Cells Internal medicine Diabetes mellitus medicine Animals Endocrine system Artificial endocrine pancreas General Veterinary business.industry Insulin General Medicine medicine.disease Streptozotocin Rats Transplantation Sexual Dysfunction Physiological Sexual dysfunction Endocrinology Hyperglycemia Female Animal Science and Zoology medicine.symptom business medicine.drug |
| Zdroj: | Experimental Animals. 59:515-519 |
| ISSN: | 1881-7122 1341-1357 |
| Popis: | We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse beta cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse beta cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380-450 mg/dl induced by streptozotocin to 140-230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin. |
| Databáze: | OpenAIRE |
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