Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

Autor:	Katharina Schulenburg, Attila Reményi, Gábor Glatz, Krishnaraj Rajalingam
Rok vydání:	2014
Předmět:	MAPK/ERK pathway Inhibitor of apoptosis domain Cancer Research Akt/PKB signaling pathway Chemistry MAPK cascade Inhibitor of apoptosis MAP2K7 XIAP Cell biology Cancer research Molecular Medicine Author's View Protein kinase B
Zdroj:	Molecular & Cellular Oncology. 1:e969170
ISSN:	2372-3556
DOI:	10.4161/23723548.2014.969170
Popis:	Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5015944b1bd8d408c4258210c86ae371 https://doi.org/10.4161/23723548.2014.969170 Zobrazit plný text záznamu