Medical and household characteristics associated with methicillin resistant Staphylococcus aureus nasal carriage among patients admitted to a rural tertiary care hospital

Autor: Kerri L. Augustino, Steven B Wing, David B. Richardson, Delores L. Nobles, Jill R. Stewart, Keith M. Ramsey, Leah Schinasi, Pia D. M. MacDonald
Rok vydání: 2012
Předmět:
Male
Pediatrics
Epidemiology
lcsh:Medicine
medicine.disease_cause
0302 clinical medicine
Patient Admission
Residence Characteristics
Medicine
030212 general & internal medicine
Young adult
lcsh:Science
0303 health sciences
Multidisciplinary
Medical record
Middle Aged
3. Good health
Bacterial Pathogens
Infectious diseases
Female
Public Health
Nasal Cavity
Research Article
Adult
Methicillin-Resistant Staphylococcus aureus
medicine.medical_specialty
Staphylococcus aureus
Adolescent
Clinical Research Design
Hospitals
Rural
Bacterial diseases
Microbiology
Infectious Disease Epidemiology
03 medical and health sciences
Young Adult
Internal medicine
Nosocomial infections
North Carolina
Humans
Biology
Aged
Survey Research
030306 microbiology
business.industry
Public health
lcsh:R
Case-control study
Odds ratio
Methicillin-resistant Staphylococcus aureus
Carriage
Case-Control Studies
lcsh:Q
business
Zdroj: PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e73595 (2013)
ISSN: 1932-6203
Popis: Extracted text; Background Methicillin resistant Staphylococcus aureus (MRSA) poses a threat to patient safety and public health. Understanding how MRSA is acquired is important for prevention efforts. This study investigates risk factors for MRSA nasal carriage among patients at an eastern North Carolina hospital in 2011. Methods Using a case-control design, hospitalized patients ages 18 – 65 years were enrolled between July 25, 2011 and December 15, 2011 at Vidant Medical Center, a tertiary care hospital that screens all admitted patients for nasal MRSA carriage. Cases, defined as MRSA nasal carriers, were age and gender matched to controls, non-MRSA carriers. In-hospital interviews were conducted, and medical records were reviewed to obtain information on medical and household exposures. Multivariable conditional logistic regression was used to derive odds ratio (OR) estimates of association between MRSA carriage and medical and household exposures. Results In total, 117 cases and 119 controls were recruited to participate. Risk factors for MRSA carriage included having household members who took antibiotics or were hospitalized (OR: 3.27; 95% Confidence Interval (CI): 1.24–8.57) and prior hospitalization with a positive MRSA screen (OR: 3.21; 95% CI: 1.12–9.23). A lower proportion of cases than controls were previously hospitalized without a past positive MRSA screen (OR: 0.40; 95% CI: 0.19–0.87). Conclusion These findings suggest that household exposures are important determinants of MRSA nasal carriage in hospitalized patients screened at admission.
Databáze: OpenAIRE
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