How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?
| Autor: | Abbas Salmani, Fatemeh Mohseni, Mohammad Hossein Karimi, Esmat Rigi Yousofabadi, Fariba Rad, Meghdad Abdollahpour-Alitappeh, Shiva Mohammadi, Hamid Najminejad, Nader Bagheri, Motahareh Mahi-Birjand, Gholam Hossein Teymouri, Mohammad Sobhani Lari, Sajad Yaghoubi, Mehran Dabaghian |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Angiogenesis Clinical Biochemistry Cell Biology Exosomes Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Ischemia Neoplasms Tumor Microenvironment Genetics medicine Animals Humans Secretion Hypoxia Molecular Biology Tumor microenvironment Neovascularization Pathologic Cell Biology Hypoxia (medical) medicine.disease Microvesicles 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research medicine.symptom Signal transduction |
| Zdroj: | IUBMB Life. 72:1286-1305 |
| ISSN: | 1521-6551 1521-6543 |
| DOI: | 10.1002/iub.2275 |
| Popis: | Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell-derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells. |
| Databáze: | OpenAIRE |
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