PPDPF Promotes the Progression and acts as an Antiapoptotic Protein in Non-Small Cell Lung Cancer
| Autor: | Deng Yuezhen, Zeng Zimei, Nie Yingjie, Li Yingzi, Li Zhi, Liu Guanxin, Cao Zhen, Mu Yun, Zhou Chengzhi, Chen Tao, Gao Jie, Sun Lunquan |
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| Rok vydání: | 2022 |
| Předmět: |
Lung Neoplasms
Carcinogenesis Down-Regulation Mice Nude NSCLC Applied Microbiology and Biotechnology Mice MDM2 Carcinoma Non-Small-Cell Lung Cell Line Tumor medicine Animals Humans Lung cancer Molecular Biology Ecology Evolution Behavior and Systematics Chemistry BABAM2 Intracellular Signaling Peptides and Proteins Cell Biology PPDPF Prognosis medicine.disease Xenograft Model Antitumor Assays respiratory tract diseases Up-Regulation radioresistance Antiapoptotic protein Disease Progression Cancer research Non small cell Apoptosis Regulatory Proteins Research Paper Developmental Biology |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | Resistance to radiotherapy is frequently observed in the clinic and leads to poor prognosis of non-small cell lung cancer (NSCLC). How to overcome resistance to radiotherapy is a challenge in the treatment of NSCLC. In this study, PPDPF was found to be upregulated in NSCLC tissues and cell lines, and its expression negatively correlated with the overall survival of patients with NSCLC. PPDPF promoted the growth, colony formation and invasion of lung cancer cells. Moreover, knockout of PPDPF inhibited tumorigenesis in the KL (KrasG12D; LKB1f/f) mouse model of lung cancer. Additionally, overexpression of PPDPF led to radioresistance in lung cancer cells, and knockdown of PPDPF sensitized lung cancer cells to radiotherapy. Mechanistically, PPDPF interacted with BABAM2 (an antiapoptotic protein) and blocked its ubiquitination by MDM2, thus stabilizing BABAM2 and promoting the radioresistance of lung cancer cells. Our present study suggested PPDPF as a therapeutic target in NSCLC. |
| Databáze: | OpenAIRE |
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