Prognostic factors to predict the survival in patients with advanced gastric cancer who receive later-line nivolumab monotherapy-The Asahikawa Gastric Cancer Cohort Study (AGCC)
| Autor: | Takahiro Sasaki, Kyoko Uehara, Shiro Yokohama, Shin Kashima, Hiroki Tanabe, Chisato Ishikawa, Mishie Tanino, Masaki Taruiishi, Yuki Murakami, Naoyuki Yanagida, Kentaro Moriichi, Yasuo Sumi, Hiromitsu Akabane, Mitsuru Goto, Katsuyoshi Ando, Mikihiro Fujiya, Sayaka Yuzawa, Yu Kobayashi, Takehito Kunogi, Yuya Sugiyama, Toshikatsu Okumura, Yohei Kitano, Keisuke Sato, Kazuyuki Tanaka, Nobuhiro Ueno, Hiroki Sato, Keitaro Takahashi, Kimiharu Hasegawa, Yusuke Mizukami |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Multivariate analysis Neutrophils medicine.medical_treatment Kaplan-Meier Estimate chemotherapy nomogram Leukocyte Count Antineoplastic Agents Immunological Stomach Neoplasms Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Lymphocytes Prospective Studies gastric carcinoma RC254-282 Research Articles Aged Proportional Hazards Models Aged 80 and over Chemotherapy business.industry Bone metastasis Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Clinical Cancer Research Nomogram Middle Aged medicine.disease Prognosis Nivolumab Cohort biomarker Female microsatellite instability business Cohort study Research Article |
| Zdroj: | Cancer Medicine Cancer Medicine, Vol 11, Iss 2, Pp 406-416 (2022) |
| ISSN: | 2045-7634 |
| Popis: | Background Chemotherapy for advanced gastric cancer is recommended in the guidelines; however, later‐line treatment remains controversial. Since immune checkpoint inhibitors have been used for the treatment of various malignancies, trials have been performed for gastric cancer. A phase 3 trial indicated the survival benefit of nivolumab monotherapy for gastric cancer patients treated with prior chemotherapy regimens. Patients and methods A regional cohort study was undertaken to determine the real‐world data of nivolumab treatment for patients with advanced or recurrent gastric cancer. The patients were enrolled for 2 years from October 2017 to October 2019 and were prospectively followed for 1 year to examine the overall survival (OS). The patient characteristics were analyzed in a multivariate analysis and a nomogram to predict the probability of survival was generated. Results In total, 70 patients who received nivolumab as ≥third‐line chemotherapy were included in the Asahikawa Gastric Cancer Cohort. The median OS was 7.5 (95% CI, 4.8–10.2) months and the response rate was 18.6%. Diffuse type classification, bone metastasis, high neutrophil/lymphocyte ratio, and high CRP were associated with poor OS/prognosis in the multivariate analysis. A nomogram was developed based on these clinical parameters and the concordance index was 0.80 (95% CI, 0.68–0.91). The responders were aged and were frequently diagnosed with intestinal type gastric cancer, including patients with a HER2‐positive status (27.3%) or microsatellite instability‐high (27.3%) status. Conclusions The regional cohort study of nivolumab monotherapy for gastric cancer patients revealed prognostic factors and a nomogram was developed that could predict the probability of survival. Development and validation of the nomogram. The nomogram of different risk factors for survival at 7.5 months in gastric cancer patients treated with nivolumab. |
| Databáze: | OpenAIRE |
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