The prognosis of subjects showing a reduced estimated glomerular filtration rate without albuminuria in Japanese patients with type 2 diabetes: a cohort study for diabetic kidney disease

Autor: Tomoko Yamasaki, Suzuko Matsumoto, Eiji Kusano, Shinichi Antoku, Toshiko Mori, Michiko Togane, Hiroyuki Ito, Takuma Izutsu
Rok vydání: 2020
Předmět:
Male
Nephrology
medicine.medical_specialty
Physiology
Population
030232 urology & nephrology
Urology
Renal function
Type 2 diabetes
030204 cardiovascular system & hematology
urologic and male genital diseases
Diabetic nephropathy
03 medical and health sciences
0302 clinical medicine
Japan
Risk Factors
Physiology (medical)
Internal medicine
medicine
Albuminuria
Humans
Diabetic Nephropathies
Prospective Studies
Mortality
education
Aged
Proportional Hazards Models
Aged
80 and over
education.field_of_study
urogenital system
Proportional hazards model
business.industry
Incidence
Middle Aged
Prognosis
medicine.disease
female genital diseases and pregnancy complications
Diabetes Mellitus
Type 2
Cardiovascular Diseases
Creatinine
Kidney Failure
Chronic
Female
medicine.symptom
business
Glomerular Filtration Rate
Kidney disease
Zdroj: Clinical and Experimental Nephrology. 24:1033-1043
ISSN: 1437-7799
1342-1751
Popis: To determine the renal and cardiovascular prognosis and all-cause mortality of Japanese patients with type 2 diabetes showing a reduced estimated glomerular filtration rate (eGFR) without albuminuria. A population of 675 patients with type 2 diabetes was prospectively observed for 4 years to determine the renal and cardiovascular outcomes and mortality. The subjects were divided into the four groups: those with a preserved eGFR and no albuminuria (n = 306), a preserved eGFR and albuminuria (n = 151), a reduced eGFR and no albuminuria (n = 96), and a reduced eGFR and albuminuria (n = 122). The Cox proportional hazard model and Fine and Gray method were used to assess between-group differences in the risk of mortality and cardiovascular events. In the group with a reduced eGFR, the eGFR value did not significantly change in the subjects without albuminuria (0 ± 8 mL/min/1.73 m2), whereas it decreased continuously in those with albuminuria (-6 ± 12 mL/min/1.73 m2). The incidence of cardiovascular events was significantly (P = 0.03) higher in the subjects with albuminuria (17%) than those without albuminuria (7%) in the group with a reduced eGFR. Cardiovascular events were significantly (P
Databáze: OpenAIRE
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