Aspergillus niger infection in an immunosuppressed patient confined solely to the brain
| Autor: | Sian Mitchell, David W. Denning, Shanika A. Crusz, Lucy Simmonds, B. D. White |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Voriconazole Medicine(all) medicine.medical_specialty Posaconazole medicine.diagnostic_test business.industry 030106 microbiology General Medicine medicine.disease Aspergillosis Aspergillus niger infection Article Surgery 03 medical and health sciences Rheumatoid arthritis Biopsy medicine Methotrexate business Stroke medicine.drug |
| Zdroj: | Simmonds, L, Mitchell, S, White, B, Crusz, S A & Denning, D 2017, ' Aspergillus niger infection in an immunosuppressed patient confined solely to the brain ', BMJ Case Reports, vol. 2017 . https://doi.org/10.1136/bcr-2016-218658 |
| Popis: | A 68-year-old woman with a background of hypertension, stroke and rheumatoid arthritis presented to her local hospital after a 4-week history of gradual deterioration and increasing confusion with new onset right-sided weakness. Her initial CT scan revealed a rim enhancing mass lesion with surrounding oedema in the left parietal lobe for which she underwent CT stealth-guided biopsy. Microbiology culture of the 2 biopsy samples yielded Aspergillus niger and she was started on the antifungal agent voriconazole. MRI 2 weeks after the procedure also demonstrated radiological findings consistent with intracranial aspergillosis. She later developed leucopenia with neutrophils of 1.5×109/L and her methotrexate and voriconazole were stopped. Voriconazole was changed to oral posaconazole. She did not undergo surgical resection and has continued to improve clinically on posaconazole, with recovery in her white cell count. |
| Databáze: | OpenAIRE |
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