Different effects of allergic rhinitis on nasal mucosa remodeling in chronic rhinosinusitis with and without nasal polyps

Autor: Rong Xiang, Yuqin Deng, Shi-Ming Chen, Qing-ping Zhang, Lu Tan, Zezhang Tao, Yu Xu, Yonggang Kong, Wei Zhang
Jazyk: angličtina
Rok vydání: 2018
Předmět:
CD31
Adult
Male
medicine.medical_specialty
Adolescent
Blotting
Western
H&E stain
Mucous membrane of nose
Periodic acid–Schiff stain
Gastroenterology
Allergic rhinitis
Masson's trichrome stain
Transforming Growth Factor beta1
03 medical and health sciences
Young Adult
0302 clinical medicine
Nasal Polyps
Internal medicine
medicine
otorhinolaryngologic diseases
Humans
Nasal polyps
030223 otorhinolaryngology
Aged
Tissue Inhibitor of Metalloproteinase-1
business.industry
Nasal polyp
General Medicine
Eosinophil
respiratory system
Rhinology
Middle Aged
medicine.disease
Immunohistochemistry
Rhinitis
Allergic
Remodeling
Nasal Mucosa
medicine.anatomical_structure
Chronic rhinosinusitis
Otorhinolaryngology
Matrix Metalloproteinase 9
030220 oncology & carcinogenesis
Chronic Disease
Female
Collagen
business
Zdroj: European Archives of Oto-Rhino-Laryngology
ISSN: 1434-4726
0937-4477
Popis: Background Allergic rhinitis (AR) has been reported to be associated with chronic rhinosinusitis (CRS). The objective of this study was to investigate the effect of AR on nasal mucosa remodeling in CRS. Methods Patients were enrolled and divided into the following groups: CRS with nasal polyps (NP) with allergic rhinitis (AR)(CRSwNPwAR; n = 20), CRS with NP without AR (CRSwNPsAR; n = 20), CRS without NP with AR (CRSsNPwAR; n = 20), CRS without NP without AR (CRSsNPsAR; n = 20), AR without CRS (AR; n = 20) and controls (n = 14). Eosinophil infiltration, mucus production, and collagen deposition were examined by hematoxylin and eosin, periodic acid schiff and masson’s trichrome staining, respectively. VEGF-A and microvessel density were detected by immunohistochemistry. The expression of remodeling markers, including TGF-β1, MMP-7, MMP-9 and TIMP-1 were measured by Western blot. Results The expression of remodeling factors, including VEGF-A, CD31, CD34 and TIMP-1 were significantly increased in CRSwAR compared to CRSsAR. Goblet cell hyperplasia, as well as VEGF-A, CD31, CD34, and MMP-9 expression were significantly higher in CRSwNPwAR compared to CRSwNPsAR. However, the expression of collagen fibers, MMP-7 and TGF-β1 were significantly higher in CRSsNPwAR compared to CRSsNPsAR. Conclusions AR could enhance the remodeling process in CRS. Moreover, AR had different effects on CRSwNP and CRSsNP.
Databáze: OpenAIRE
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