Ellagic acid ameliorates hexavalent chromium-induced renal toxicity by attenuating oxidative stress, suppressing TNF-α and protecting mitochondria

Autor:	Mayra Yael Cuevas-Magaña, Claudia Cecilia Vega-García, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Cecilia Zazueta, Wylly Ramsés García-Niño
Rok vydání:	2022
Předmět:	Pharmacology Chromium Male Nitrogen Tumor Necrosis Factor-alpha Toxicology Kidney Antioxidants Mitochondria Rats Oxidative Stress Ellagic Acid Creatinine Animals Urea Rats Wistar Protein Kinases Biomarkers
Zdroj:	Toxicology and applied pharmacology. 454
ISSN:	1096-0333
Popis:	Nephrotoxicity is an important adverse effect of oxidative stress induced by hexavalent chromium [Cr(VI)]. The effect of ellagic acid, a dietary polyphenolic compound with potent antioxidant activity, was investigated in Cr(VI)-induced kidney injury. Six groups of male Wistar rats were treated intragastrically with vehicle or ellagic acid (15 and 30 mg/kg) for 10 days. On day 10, rats received saline or Cr(VI) (K
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500a02e4586a8ec41245782e1d1390f8 https://pubmed.ncbi.nlm.nih.gov/36108929 Zobrazit plný text záznamu Full Text from ScienceDirect