Methionine Synthesis, Aminoimidazole Carboxamide Excretion and Folate Levels in Pregnant Rats
| Autor: | G. Bourdel, M. Goubern, F. N'Diaye, G. Potier de Courcy, Y. Hitier |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Hydroxymethyl and Formyl Transferases
medicine.medical_specialty Glutamate Formimidoyltransferase Medicine (miscellaneous) Dehydrogenase 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Excretion chemistry.chemical_compound Folic Acid Methionine Pregnancy Transferases Internal medicine medicine Animals Methionine synthase Tetrahydrofolates Glycine Hydroxymethyltransferase Methylenetetrahydrofolate Dehydrogenase (NADP) Fetus Nutrition and Dietetics Homocystine biology Body Weight Imidazoles Glutamate receptor Aminoimidazole Carboxamide medicine.disease Diet Rats Endocrinology Liver chemistry Biochemistry biology.protein Pregnancy Animal Female |
| Zdroj: | The Journal of Nutrition. 110:522-531 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/110.3.522 |
| Popis: | The capacity for tetrahydrofolate regeneration through folate-linked methionine synthesis and for purine-ring closure through formylation of aminoimidazole carboxamide ribotide was studied in pregnant female rats fed diets containing either methionine or homocystine with or without folic acid. Plasma and liver folates, serine transhydroxymethylase, 5,10-methylene tetrahydrofolate dehydrogenase and glutamate formiminotransferase activities were also assayed. Pregnancy proceeded normally in all groups. Hypotrophic fetuses were observed only with the diet containing homocystine and no folic acid. Plasma folates were severely depleted at the end of pregnancy even when folic acid was present in the diet. Hepatic stores of folate were twice as high in the methionine as in the homocystine-fed pregnant females supplemented with folic acid. This favorable effect of methionine was not observed in folic acid-deficient females. No change in levels of serine transhydroxymethylase, 5,10-methylenetetrahydrofolate dehydrogenase, glutamate formimino-transferase activities was observed. Pregnancy did not stimulate methionine synthetase activity, the level of which was primarily affected by the nutritional conditions. Because of its low output and narrow range of adaptativity, methionine synthetase cannot be the sole regulatory factor of THF regeneration. Urinary excretion of aminoimidazole carboxamide was enhanced in folic acid-deficient pregnant females and was not prevented by supplying methionine. |
| Databáze: | OpenAIRE |
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