The GGN and CAG repeat polymorphisms in the exon-1 of the androgen receptor gene are, respectively, associated with insulin resistance in men and with dyslipidemia in women
| Autor: | Cristina Bilbao, Pedro C. Lara, Laura López-Ríos, Patricia Barber Pérez, B. Nicolás Díaz-Chico, Germán Rodríguez-González, Juan C. Díaz-Chico, Ricardo Chirino, Lluis Serra-Majem, Raquel Ramírez-Moreno |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Biology Biochemistry Exon Young Adult Endocrinology Insulin resistance Trinucleotide Repeats Internal medicine medicine Humans Genetic Predisposition to Disease Allele Child Molecular Biology Pancreatic hormone Aged Dyslipidemias Polymorphism Genetic Insulin Cell Biology Exons Middle Aged medicine.disease Androgen receptor Receptors Androgen Spain Child Preschool Molecular Medicine Female Insulin Resistance Body mass index Dyslipidemia |
| Zdroj: | The Journal of steroid biochemistry and molecular biology. 113(3-5) |
| ISSN: | 1879-1220 |
| Popis: | The human androgen receptor (AR) gene possesses two trinucleotide repeats of CAG and GGN in exon-1. The GGN repeat affects the amount of AR protein translated, while the CAG repeat affects the efficiency of AR transcriptionaly. In this study, we have genotyped these polymorphic tracts in a representative sample of 557 Caucasian adult individuals (314 women and 243 men) from the Canary Islands, Spain (the ENCA Study), and investigated their association with fasting serum levels of lipids, glucose and insulin. The number of CAG repeats in women (expressed as the average length of the two alleles) was inversely correlated with serum levels of LDL-cholesterol (Spearman rho=-0.179; P |
| Databáze: | OpenAIRE |
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