Patterns of clozapine and other antipsychotics prescriptions in patients with treatment-resistant schizophrenia in community mental health centers in São Paulo, Brazil
| Autor: | Cecília Attux, Helio Elkis, Leticia Aparecida da Silva, Deyvis Rocha, Claudiane Salles Daltio, John M. Kane, Rodrigo A. Bressan, Ana Stella de Azevedo Silveira |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Polypharmacy
medicine.medical_specialty drug resistance clozapine business.industry medicine.drug_class lcsh:RC435-571 medicine.medical_treatment Atypical antipsychotic antipsychotic agents medicine.disease Typical antipsychotic drug prescriptions Psychiatry and Mental health Schizophrenia lcsh:Psychiatry Community health medicine Medical prescription business Antipsychotic Psychiatry Clozapine medicine.drug |
| Zdroj: | Revista de Psiquiatria Clínica; Vol. 42 Núm. 6 (2015); 165-170 Archives of Clinical Psychiatry; v. 42 n. 6 (2015); 165-170 Archives of Clinical Psychiatry; Vol. 42 No. 6 (2015); 165-170 Archives of Clinical Psychiatry Universidade de São Paulo (USP) instacron:USP Archives of Clinical Psychiatry, Vol 42, Iss 6, Pp 165-170 (2015) Archives of Clinical Psychiatry (São Paulo), Volume: 42, Issue: 6, Pages: 165-170, Published: DEC 2015 |
| ISSN: | 1806-938X 0101-6083 |
| Popis: | Background Despite of its global underuse, clozapine is still the golden standard antipsychotic for patients with treatment-resistant schizophrenia (TRS). Objective To evaluate the patterns of clozapine and other antipsychotic drugs prescription in TRS in community mental health centers in São Paulo, Brazil. Methods A multiple-choice questionnaire was applied to fifteen psychiatrists at five centers inquiring about patients’ clinical condition, adherence to oral treatment and current antipsychotic treatment. History of previous and current antipsychotic treatment was collected through medical chart review. Results Out of 442 schizophrenia patients, 103 (23.3%) fulfilled the criteria for TRS. Fifty-eight patients (56.3%) were receiving polypharmacy; 30 (29.1%) were on atypical antipsychotic monotherapy, 14 (13.6%) were on typical antipsychotic monotherapy, 25 (24.3%) were taking depot antipsychotic medication and only 22 (21.4%) were receiving clozapine. Discussion As well as in other parts of the world, many TRS patients (78.6%) receive other drugs instead of clozapine in São Paulo, the best evidence-based medication for patients with TRS. The government should make every effort to provide medical training and the equipment and logistic support to adequately serve those who could benefit from clozapine treatment at the community health centers. |
| Databáze: | OpenAIRE |
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