Regenerative Treatment of Periodontal Intrabony Defects Using Autologous Dental Pulp Stem Cells: A 1-Year Follow-Up Case Series
| Autor: | Francesco Ferrarotti, Federica Romano, Marta Giraudi, Mario Aimetti, Mara Noemi Gamba |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Time Factors Alveolar Bone Loss Dentistry 1 year follow up 03 medical and health sciences stomatognathic system Dental pulp stem cells Humans Regeneration Medicine Dental Pulp business.industry Impaction Follow up studies Attachment level Middle Aged medicine.disease Chronic periodontitis 030104 developmental biology Collagen sponge Oral Surgery Periodontics Female business Follow-Up Studies Stem Cell Transplantation Gingival margin |
| Zdroj: | The International Journal of Periodontics & Restorative Dentistry. 38:51-58 |
| ISSN: | 0198-7569 |
| DOI: | 10.11607/prd.3425 |
| Popis: | The present case series aimed to explore the potential clinical benefits of the application of dental pulp stem cells (DPSCs) in the regenerative treatment of deep intrabony defects. A total of 11 isolated intrabony defects in 11 chronic periodontitis patients were accessed with a minimally invasive flap and filled with DPSCs loaded on a collagen sponge. A tooth requiring extraction for impaction or malpositioning was used as an autologous source for DPSCs. An average clinical attachment level gain of 4.7 ± 1.5 mm associated with a residual mean probing depth (PD) of 3.2 ± 0.9 mm and remarkable stability of the gingival margin was observed at 1 year. Complete pocket closure (PD < 3 mm) was achieved in 63.6% of the experimental sites. Clinical outcomes were supported by the radiographic analysis showing a bone fill of 3.6 ± 1.9 mm. |
| Databáze: | OpenAIRE |
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