Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

Autor: Marie-Christine Alessi, Pierre Fautrad, Béatrice Riteau, Noémie Courtin, Floriane Mas, Aurélien Fotso Fotso
Přispěvatelé: ALESSI, Marie-Christine, Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR ANR-13-BSV3-0011, Fondation de France 00066467, FVLM RF20160501641 SA17 Sud-Est, 789-SA-16-UAM, Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Nutrition, obésité et risque thrombotique ( NORT ), Institut National de la Recherche Agronomique ( INRA ) -Aix Marseille Université ( AMU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut National de la Recherche Agronomique ( INRA )
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
MAPK/ERK pathway
viruses
Virus Replication
virus grippal
Madin Darby Canine Kidney Cells
chemistry.chemical_compound
Mice
0302 clinical medicine
Influenza A Virus
H1N1 Subtype
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Pandemic
Formyl peptide receptor 2
Receptors
Lipoxin
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
activité antivirale
virus diseases
Haplorhini
peptide
3. Good health
Respiratory pathogens
Drug Combinations
Influenza A virus
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Female
influenza viruses
Oligopeptides
agent pathogène
Oseltamivir
Cell Survival
MAP Kinase Signaling System
Biology
[ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Antiviral Agents
03 medical and health sciences
Dogs
Virology
Influenza
Human
pandémie de grippe
Animals
Humans
Antiviral
Gelsolin
Pharmacology
Influenza A Virus
H3N2 Subtype
Influenza a
Receptors
Formyl Peptide
Peptide Fragments
Mice
Inbred C57BL
Influenza B virus
030104 developmental biology
Viral replication
chemistry
A549 Cells
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Influenza virus
Sequence Alignment
pathogen
030215 immunology
Zdroj: Antiviral Research
Antiviral Research, Elsevier Masson, 2017, 143, pp.252-261. ⟨10.1016/j.antiviral.2017.05.001⟩
Antiviral Research, Elsevier Masson, 2017, 143, pp.252-261. 〈10.1016/j.antiviral.2017.05.001〉
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2017.05.001⟩
Popis: International audience; Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation. Finally, our preclinical studies showed that FPR2 antagonists protected mice from lethal infections induced by influenza, both in a prophylactic and therapeutic manner. Thus, FPR2 antagonists might be explored for novel treatments against influenza.
Databáze: OpenAIRE
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