Antihyperglycaemia and related gene expressions of aqueous extract of Gongronema latifolium leaf in alloxan-induced diabetic rats

Autor: Basiru Olaitan Ajiboye, Emeka Asogwa, Abidemi Paul Kappo, Sunday Amos Onikanni, Babatunji Emmanuel Oyinloye, Precious Eseose Agboinghale
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Blood Glucose
Pharmaceutical Science
Gongronema
intraperitoneal
030226 pharmacology & pharmacy
01 natural sciences
Lipid peroxidation
chemistry.chemical_compound
0302 clinical medicine
Diabetes mellitus
Alloxan
Hexokinase
Drug Discovery
Insulin
Related gene
Medicinal plants
ethnobotanical doses
Traditional medicine
lipid peroxidation
General Medicine
Liver
Models
Animal
Glucose-6-Phosphatase
Molecular Medicine
Female
Glycogen
Research Article
food.ingredient
Blood sugar
Context (language use)
RM1-950
Biology
Diabetes Mellitus
Experimental
03 medical and health sciences
food
hexokinase
GLUT-2
medicine
Animals
Hypoglycemic Agents
Rats
Wistar
Pharmacology
Glycated Hemoglobin
GLUT-4
Plant Extracts
medicine.disease
0104 chemical sciences
Rats
Apocynaceae
Plant Leaves
010404 medicinal & biomolecular chemistry
Glucose
Complementary and alternative medicine
chemistry
Therapeutics. Pharmacology
Phytotherapy
Zdroj: Pharmaceutical Biology
Pharmaceutical Biology, Vol 57, Iss 1, Pp 604-611 (2019)
ISSN: 1744-5116
1388-0209
Popis: Context: Gongronema latifolium Benth (Asclepiadaceae) has been highly utilized in controlling diabetes mellitus traditionally in the eastern part of Nigeria. Objectives: Antihyperglycaemic and related gene expressions of aqueous extract of Gongronema latifolium leaf in alloxan-induced diabetic rats. Materials and methods: Forty-eight female Wistar rats were induced intraperitoneally using alloxan (150 mg/kg body weight). The rats were separated into six groups (n = 8) as follows: non-diabetic control, diabetic control, diabetic rats administered 5 mg/kg body weight of metformin, and diabetic rats administered 6.36, 12.72 and 25.44 mg/kg body weight (ethnobotanical doses) of G. latifolium orally daily. On the 14th day, the animals were sacrificed and different antihyperglycaemic parameters were evaluated as well as its related gene expressions. Results: Diabetic rats administered three doses of aqueous extract of G. latifolium significantly (p
Databáze: OpenAIRE
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