| Autor: |
Amy B. Heimberger, George A. Calin, Gregory N. Fuller, Ganesh Rao, Frederick F. Lang, Nicholas B. Levine, Wei Qiao, Olsi Gjyshi, Krishan Jethwa, Kayla McEnery, Yuhui Yang, Sherise D. Ferguson, Tiffany Doucette, Shuo Xu, Ling-Yuan Kong, Fei Wang, Jun Wei |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22394877 |
| Popis: |
Supplementary Figure 3 - PDF file 37K, miR-21 expression is higher in gCSCs and glioblastoma tumors than in normal brain and is inhibited by miR-124 overexpression. (A) Relative expression levels of miR-21 were detected by TaqMan quantitative P CR. There were significant differences in the relative expression levels of miR-21 between normal brain tissues, gCSCs and GBM specimens. (B) T-cell proliferation was detected by flow cytometry analysis with CFSE staining after 3 days of treatment with medium alone, gCSC-scramble-transfected conditioned medium, or gCSC-miR-21-transfected conditioned medi um. miR-21 up regulation caused further inhibition in T-cell proliferation compared with the gCSC-scramble-transfected conditioned medium. (C) Forced overexpression of miR-124 in the gCSCs resulted in the down modulation of miR-21 expression |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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