Enantioselective Access to Spirolactams via Nitrenoid Transfer Enabled by Enhanced Noncovalent Interactions

Autor:	Sukbok Chang, Dong-Wook Kim, Yeong Bum Kim, Yeongyu Hwang, Euijae Lee
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Colloid and Surface Chemistry Chemistry Enantioselective synthesis Non-covalent interactions General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Catalysis 0104 chemical sciences
Zdroj:	Journal of the American Chemical Society. 143(17)
ISSN:	1520-5126
Popis:	Described herein is the Ir-catalyzed enantioselective access to chiral spirolactam products via the nitrenoid transfer to aromatic ipso-carbons. The key strategy for precise stereocontrol is to enhance the secondary attractive and repulsive interactions between the chiral catalyst and substrates by the introduction of a traceless O-silyl achiral auxiliary, thus effectively differentiating two prochiral faces of arenol-derived 1,4,2-dioxazol-5-one substrates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50019e44366c256b839ee5941d460532 https://pubmed.ncbi.nlm.nih.gov/33886287 Zobrazit plný text záznamu