Infrared spectroscopy characterization of normal and lung cancer cells originated from epithelium
| Autor: | Dembereldorj Uuriintuya, Sang-Woo Joo, Soo Hwa Jang, Kyong Ah Yoon, So Yeong Lee, Pan Dong Ryu, Erdene-Ochir Ganbold, Sang Mo Shin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Neoplasms cancer cell screening Spectrophotometry Infrared Infrared Infrared spectroscopy Respiratory Mucosa lung cancers Nuclear magnetic resonance Cell Line Tumor medicine Humans Spectroscopy Lung cancer infrared spectroscopy General Veterinary cell monitoring Chemistry phosphorylation Carcinoma Epithelial Cells medicine.disease Cell culture Attenuated total reflection Cancer cell Phosphodiester bond Original Article |
| Zdroj: | Journal of Veterinary Science |
| ISSN: | 1976-555X 1229-845X |
| Popis: | The vibrational spectral differences of normal and lung cancer cells were studied for the development of effective cancer cell screening by means of attenuated total reflection infrared spectroscopy. The phosphate monoester symmetric stretching nu(s)(PO3(2-)) band intensity at ~970 cm(-1) and the phosphodiester symmetric stretching nu(s)(PO2(-)) band intensity at approximately 1,085 cm(-1) in nucleic acids and phospholipids appeared to be significantly strengthened in lung cancer cells with respect to the other vibrational bands compared to normal cells. This finding suggests that more extensive phosphorylation occur in cancer cells. These results demonstrate that lung cancer cells may be prescreened using infrared spectroscopy tools. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|