Microbial colonization and lung function in adolescents with cystic fibrosis
| Autor: | Ute Graepler-Mainka, Tobias Kirn, Matthias Kappler, Ingo B. Autenrieth, Michael Hogardt, Ernst Eber, Marlies Wagner, Anjali Ralhan, Joachim Riethmueller, Sina Berenbrinker, Matthias Griese, Peter Martus, Andreas Pfleger, Andreas Hector, Dominik Hartl |
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| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male Methicillin-Resistant Staphylococcus aureus Adolescent Cystic Fibrosis Statistics as Topic medicine.disease_cause Staphylococcal infections Cystic fibrosis Haemophilus influenzae Microbiology 03 medical and health sciences 0302 clinical medicine Germany medicine Humans Clinical significance Colonization Pseudomonas Infections 030212 general & internal medicine Lung Pseudomonas aeruginosa business.industry Aspergillus fumigatus Staphylococcal Infections medicine.disease Methicillin-resistant Staphylococcus aureus Respiratory Function Tests medicine.anatomical_structure 030228 respiratory system Austria Pediatrics Perinatology and Child Health Immunology Microbial Interactions Female Pulmonary Aspergillosis business |
| Zdroj: | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 15(3) |
| ISSN: | 1873-5010 |
| Popis: | With intensified antibiotic therapy and longer survival, patients with cystic fibrosis (CF) are colonized with a more complex pattern of bacteria and fungi. However, the clinical relevance of these emerging pathogens for lung function remains poorly defined. The aim of this study was to assess the association of bacterial and fungal colonization patterns with lung function in adolescent patients with CF. Microbial colonization patterns and lung function parameters were assessed in 770 adolescent European (German/Austrian) CF patients in a retrospective study (median follow-up time: 10years). Colonization with Pseudomonas aeruginosa and MRSA were most strongly associated with loss of lung function, while mainly colonization with Haemophilus influenzae was associated with preserved lung function. Aspergillus fumigatus was the only species that was associated with an increased risk for infection with P. aeruginosa. Microbial interaction analysis revealed three distinct microbial clusters within the longitudinal course of CF lung disease. Collectively, this study identified potentially protective and harmful microbial colonization patterns in adolescent CF patients. Further studies in different patient cohorts are required to evaluate these microbial patterns and to assess their clinical relevance. |
| Databáze: | OpenAIRE |
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