| Autor: |
Hatem E. Sabaawy, Joseph Bertino, Robert S. DiPaola, Thomas W. Davis, Isaac Y. Kim, Mark N. Stein, John Kerrigan, Daniel Medina, Hua Zhong, Young-Choon Moon, Nadiya Sydorenko, Liangxian Cao, Daniel Jones, Michele Patrizii, Eric Huselid, Kathleen Flaherty, Stephani Davis, Shamila Yusuff, Monica Bartucci, Nitu Bansal |
| Rok vydání: |
2023 |
| Popis: |
Supplementary data Figure S1. Functional role(s) of BMI-1 in PCa. Figure S2. BMI-1 expression in subpopulations of DU145 cells. Figure S3. Pharmacological inhibition of BMI-1. Figure S4. Molecular and cellular effects of pharmacological targeting of BMI-1. Figure S5. Examining BMI-1 inhibitors in toxicological assays and effects on normal cells. Figure S6. Toxicity effects of C-209 and CHX on adult and embryo zebrafish. Figure S7. BMI-1 inhibition effect on the normal prostate and hematopoietic system. Figure S8. Representative images of BMI-1 expression in primary PCa samples. Figure S9. Xenografts of human primary PCa cells in embryonic zebrafish. Figure S10. Xenografts of primary PCa tissue in zebrafish embryos. Figure S11. Toxicology assays of chemotherapy and BMI-1 inhibitors in embryonic zebrafish. Figure S12. Anti-tumor activity of BMI-1 inhibitors. Figure S13. Representative H&E staining of mouse xenograft sections indicating the histological effects of treatments. Figure S14. In vivo pharmacological targeting of BMI-1 in androgen independent DU145 and androgen sensitive 22rv1 PCa mouse xenografts. Figure S15. Colony-formation frequency evaluated by dilution analysis of xenograft-derived cells from untreated mice and mice treated with C-209 60mg/kg/day. Figure S16. BMI-1 inhibition effects on androgen-dependent and -independent cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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