Virological outcome among HIV-1 infected patients on first-line antiretroviral treatment in semi-rural HIV clinics in Togo
| Autor: | Mounerou Salou, Pyabalo Kpanla, Assetina Singo-Tokofaï, Anoumou Y. Dagnra, Eric Delaporte, Nicole Vidal, Pascal Kodah, Damobé Kombate, Mireille Prince-David, Tchabia Nabroulaba, Martine Peeters, Palokinam Pitché, Djifa Nyametso, Abla A. Konou |
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| Přispěvatelé: | Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques er émergentes (TransVIHMI), Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université Montpellier 1 (UM1), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Université de Yaoundé I-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Short Report Etravirine Drug resistance 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Abacavir Virology Internal medicine medicine Pharmacology (medical) 030212 general & internal medicine Didanosine Public health 0303 health sciences Traditional medicine Semi-rural 030306 microbiology business.industry HIV 3. Good health Antiretroviral treatment chemistry Togo Rilpivirine Africa Molecular Medicine Population study Rural area business medicine.drug |
| Zdroj: | AIDS Research and Therapy AIDS Research and Therapy, BioMed Central, 2015, 12 (1), pp.38. ⟨10.1186/s12981-015-0082-7⟩ AIDS Research and Therapy, 2015, 12 (1), pp.38. ⟨10.1186/s12981-015-0082-7⟩ |
| ISSN: | 1742-6405 |
| DOI: | 10.1186/s12981-015-0082-7 |
| Popis: | International audience; BACKGROUND:Access to antiretroviral treatment (ART) in resource-limited countries has increased significantly but scaling-up ART into semi-rural and rural areas is more recent. Information on treatment outcome in such areas is still very limited notably due to additional difficulties to manage ART in these areas.RESULTS:387 HIV-1 infected adults (≥18 years) were consecutively enrolled when attending healthcare services for their routine medical visit at 12 or 24 months on first-line ART in five HIV care centers (four semi-rural and one rural). Among them, 102 patients were on first-line ART for 12 ± 2 months (M12) and 285 for 24 ± 2 months (M24). Virological failure was observed in 70 (18.1 %) patients ranging from 13.9 to 31.6 % at M12 and from 8.1 to 22.4 % at M24 across the different sites. For 67/70 patients, sequencing was successful and drug resistance mutations were observed in 65 (97 %). The global prevalence of drug resistance in the study population was thus at least 16.8 % (65/387). Moreover, 32 (8.3 %) and 27 (6.9 %) patients were either on a completely ineffective ART regime or with only a single drug active. Several patients accumulated high numbers of mutations and developed also cross-resistance to abacavir, didanosine or the new NNRTI drugs like etravirine and rilpivirine.CONCLUSION:The observations on ART treatment outcome from ART clinics in semi-rural areas are close to previous observations in Lomé, the capital city suggesting that national ART-programme management plays a role in treatment outcome. |
| Databáze: | OpenAIRE |
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