Evaluation of Neosaxitoxin as a local anesthetic during piglet castration: A potential alternative for Lidocaine
| Autor: | Miguel del Campo, Vanina Muñoz, Carolina Valenzuela, Tamara Bustamante, Robin Piron, Juan Carlos Simbaina, Néstor Lagos, Cristian G. Torres, Joaquín M. Sepúlveda, Andrella Sánchez |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Lidocaine medicine.drug_class animal diseases media_common.quotation_subject Sus scrofa Neosaxitoxin Pain Toxicology Random Allocation chemistry.chemical_compound Pain control medicine Animals Prospective Studies Anesthetics Local media_common Inflammation integumentary system business.industry Local anesthetic Convalescence Pain management Castration chemistry Anesthesia Scrotum medicine.symptom Skin Temperature business Orchiectomy Vasoconstriction Saxitoxin medicine.drug |
| Zdroj: | Toxicon. 164:26-30 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2019.03.021 |
| Popis: | Objetive To evaluate Neosaxitoxin (NeoSTX) as a local anesthetic drug, for pain control during and after piglet castration. Study design Prospective, randomized and double-blind study. Animals 24 commercial hybrids, males, 23-day-old piglets. Methods The piglets were randomized into two groups: a Lidocaine group and a NeoSTX group. One minute before castration, they were injected intra-scrotally with a single dose of Lidocaine (20 mg, in 1 mL) and NeoSTX (0.1 μg, in 1 mL), respectively. Results NeoSTX does not generate vasoconstriction or scrotal contraction, unlike Lidocaine, where a decrease in temperature and scrotal size is observed within 5 min after the procedure. After 24 h, wound inflammation, as measured by scrotal size, was lower in the NeoSTX group. No significant difference could be shown between the vocalizations and facial expressions of pain of both groups during the castration procedure. Conclusions A single dose of NeoSTX is safe and effective for pain management during and after piglet castration. NeoSTX treated piglets were less affected by castration than those in the Lidocaine group, thus reducing piglet stress and enhancing the quality of piglet convalescence. |
| Databáze: | OpenAIRE |
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