Epstein-Barr virus (EBV) genotypes among human immunodeficiency virus (HIV)-related B-cell Lymphomas and B-cell post-transplant lymphoproliferative disorders (B-PTLD) - late-onset lymphomas, especially in the HIV setting, are associated with type-B-EBV
| Autor: | Margaret Burke, Sabine Pomplun, Kikkeri N. Naresh, Lia P. Menasce, Mark Bower, Hazem A. H. Ibrahim |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Herpesvirus 4 Human Lymphoma B-Cell Adolescent Genotype Lymphoproliferative disorders medicine.disease_cause Virus Young Adult Antigen hemic and lymphatic diseases Humans Medicine Child B cell Aged business.industry HIV Organ Transplantation Hematology General Medicine Middle Aged medicine.disease Epstein–Barr virus Virology Lymphoproliferative Disorders Lymphoma medicine.anatomical_structure Child Preschool Immunology Female business Viral load |
| Zdroj: | European Journal of Haematology. 85:227-230 |
| ISSN: | 0902-4441 |
| DOI: | 10.1111/j.1600-0609.2010.01460.x |
| Popis: | We investigated 26 B-cell post-transplant lymphoproliferative disorders (B-PTLD) and 15 human immunodeficiency virus-related aggressive B-cell lymphomas (HIV-BCL) from England that were associated with Epstein-Barr virus (EBV) for the polymorphic sequences of the EBV-encoded nuclear antigen 3C (EBNA3C) gene to distinguish the two different EBV strains. Type-A-EBV was identified in 92% of B-PTLDS and in 53% of HIV-BCL (P = 0.003). Among HIV-BCL, patients associated with type-B-EBV had been HIV positive for significantly longer when compared to those associated with type-A (P = 0.037) although there were no correlations with ethnicity, CD4 cell counts or plasma HIV viral load. |
| Databáze: | OpenAIRE |
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