Helminth genome analysis reveals conservation of extracellular vesicle biogenesis pathways but divergence of RNA loading machinery between phyla
| Autor: | Mark W. Robinson, Adam P.S. Bennett, Eduardo de la Torre-Escudero |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Comparative genomics Genome Helminth Endosome Microvesicle Protein subunit 030231 tropical medicine RNA Extracellular vesicle Helminth Proteins Biology Cell biology 03 medical and health sciences Extracellular Vesicles Protein Transport 030104 developmental biology 0302 clinical medicine Infectious Diseases Helminths parasitic diseases Animals Parasitology RNA Helminth Cytoskeleton Biogenesis |
| Zdroj: | Bennett, A, de la Torre Escudero, E & Robinson, M 2020, ' Helminth genome analysis reveals conservation of extracellular vesicle biogenesis pathways but divergence of RNA loading machinery between phyla. ', International Journal for Parasitology . https://doi.org/10.1016/j.ijpara.2020.04.004 |
| DOI: | 10.1016/j.ijpara.2020.04.004 |
| Popis: | A comparative genomics approach was used to determine whether established extracellular vesicle biogenesis pathways are conserved in helminths. This revealed conservation of membrane and cytoskeletal organising proteins as well as the endosomal sorting complex required for transport previously described in mammalian cells. Domain level analysis of this complex in helminths, however, indicated that some species may rely on atypical proteins to support subunit interactions and cargo recruitment. Interestingly, helminths displayed phylum level divergence of proteins associated with loading RNA into extracellular vesicles. These findings provide a framework for functional studies of helminth extracellular vesicle biogenesis and cargo sorting. |
| Databáze: | OpenAIRE |
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