Elevated Cerebrospinal Fluid Substance P Concentrations in Posttraumatic Stress Disorder and Major Depression
| Autor: | Dewleen G. Baker, Linda L. Carpenter, Paul S. Horn, Thomas D. Geracioti, Jeffrey R. Strawn, Gerard Sanacora, Becky Kinkead, Lawrence H. Price, Charles B. Nemeroff, Nosakhare N. Ekhator, Michael J. Owens |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Periodicity medicine.medical_specialty Provocation test Neuropeptide Substance P Neutral stimulus Spinal Puncture Subarachnoid Space Arousal Life Change Events Stress Disorders Post-Traumatic chemistry.chemical_compound Catheters Indwelling Cerebrospinal fluid Internal medicine medicine Humans Combat Disorders Depressive Disorder Major Cross-Over Studies Videotape Recording medicine.disease Crossover study Psychiatry and Mental health Endocrinology chemistry Anesthesia Acute Disease Visual Perception Psychology Photic Stimulation Stress Psychological Anxiety disorder |
| Zdroj: | American Journal of Psychiatry. 163:637-643 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | Objective: The authors tested the hypothesis that concentrations of the paintransmitting neuropeptide substance P are elevated in the CSF of patients with major depression or posttraumatic stress disorder (PTSD), which have overlapping symptoms. The authors also sought to determine if CNS substance P concentrations change on provocation of symptoms in PTSD patients. Method: The authors measured CSF substance P concentrations in medicationfree patients with either major depression or PTSD and in healthy comparison subjects. Next, using a within-subject, crossover design, the authors sampled CSF for 6 hours through an indwelling subarachnoid catheter in PTSD patients before, during, and after exposure to a 60-minute traumatic or neutral videotape stimulus. Results: Both depressed and PTSD patients had significantly elevated basal CSF substance P concentrations. In the challenge study, marked increases in CSF substance P concentrations were found only after precipitation of PTSD symptoms. CSF substance P concentrations increased by 169% and 90.6% of baseline levels at 10 and 70 minutes, respectively, after the start of the traumatic videotape but changed by only 1.1% and –8.1% of baseline levels 10 and 70 minutes after the start of the neutral videotape. Conclusions: These results suggest that elevated CNS substance P concentrations are involved in both major depression and PTSD. The marked increase in CSF substance P concentrations during and after the symptom-provoking stimulus, but not after the neutral stimulus, implicates CNS release of substance P in the mechanism of acute PTSD symptoms. These data also reveal that CNS substance P responds acutely to psychological stress |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|