Faecal occult blood test-based screening programme with high compliance for colonoscopy has a strong clinical impact on colorectal cancer
| Autor: | F, Parente, B, Marino, N, DeVecchi, R, Moretti, G, Ucci, P, Tricomi, A, Armellino, L, Redaelli, S, Bargiggia, E, Cristofori, E, Masala, F, Tortorella, A, Gattinoni, F, Odinolfi, M E, Pirola |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Adenoma Colorectal cancer Colonoscopy Pilot Projects Disease Gastroenterology Internal medicine medicine Humans Mass Screening Stage (cooking) Sex Distribution Early Detection of Cancer Aged Aged 80 and over medicine.diagnostic_test business.industry Incidence (epidemiology) Cancer Middle Aged medicine.disease Italy Occult Blood Educational Status Patient Compliance Surgery Female Faecal occult blood test business Colorectal Neoplasms |
| Zdroj: | The British journal of surgery. 96(5) |
| ISSN: | 1365-2168 |
| Popis: | Background The results of a pilot colorectal cancer screening programme by biennial immunochemical faecal occult blood test (FOBT) are reported. Methods All residents aged between 50 and 69 years in the Italian province of Lecco were invited to have a FOBT. Those with a positive result were offered colonoscopy. FOBT uptake and compliance with colonoscopy were assessed. Detection rate and positive predictive value (PPV) for cancer and adenoma were calculated. Tumour stages were compared between screen-detected cancers and other colorectal cancers diagnosed within the target age group. Results Some 38 693 (49·6 per cent) of 78 083 individuals had a FOBT and 2392 (6·2 per cent) had a positive result. Colorectal cancer was diagnosed in 4·6 per cent and advanced adenoma in 32·7 per cent. PPVs were 4·0 per cent for cancer, 28·1 per cent for advanced adenoma and 36·6 per cent for any adenoma. There was a significant difference in incidence of stage III/IV disease between screened and non-screened cohorts. Compliance for colonoscopy was 92·0 per cent. Major determinants of compliance were age less than 59 years, female sex, high education level and non-manual work. Conclusion These results justify extension of colorectal cancer screening to other regions of Italy. |
| Databáze: | OpenAIRE |
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