Local tissue response to silastic implant containing norethindrone acetate in women
| Autor: | S. Jeyaseelan, V. Hingorani, Kesho R. Laumas, U.N. Bhuyan, D. Takkar |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
medicine.medical_specialty Foreign-body giant cell Time Factors Connective tissue Peripheral blood mononuclear cell Pregnancy Internal medicine Humans Medicine Silastic implant Connective Tissue Cells Drug Implants business.industry Obstetrics and Gynecology Norethindrone Acetate Endocrinology medicine.anatomical_structure Reproductive Medicine Connective Tissue Silicone Elastomers Female Histopathology Implant Norethindrone business Subcutaneous tissue |
| Zdroj: | Contraception. 15:39-51 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/0010-7824(77)90036-1 |
| Popis: | The effect of a silastic implant made of polydimethyl siloxane tubing and containing 40 mg of norethindrone acetate has been studied in relation to its effect on the subcutaneous tissue of fifty women. Clinically, induration over the implant was detected in only one of them. The histopathology revealed connective tissue response to the silastic implant. The connective tissue showed progressive condensation and maturation of collagen and was associated with chronic inflammatory cell reaction,mainly mononuclear cells and foreign body giant cells. New capillary formation was also seen. However, no anaplastic changes of the fibroblasts were observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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