Hypotensive effect of profilin on rabbit intraocular pressure
| Autor: | Assumpta Peral, Xavier Gasull, Miguel Morales, Jesús Pintor, Azucena Gomez-Cabrero |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Intraocular pressure genetic structures Eye disease Recombinant Fusion Proteins Ocular hypertension Glaucoma macromolecular substances Thiophenes Retinal ganglion Profilins Ophthalmology medicine Animals Antihypertensive Agents Intraocular Pressure Pharmacology Sulfonamides biology business.industry Aqueous humour Pilocarpine Biological membrane medicine.disease eye diseases Surgery Protein Structure Tertiary Profilin Prostaglandins F Synthetic biology.protein Latanoprost sense organs Rabbits business |
| Zdroj: | European journal of pharmacology. 567(1-2) |
| ISSN: | 0014-2999 |
| Popis: | Ocular hypertension is a negative process that occurs within the eye and is the main risk factor to develop glaucoma, a progressive loss of vision due to degeneration of retinal ganglion cells. The protein transduction technique allows a cargo to cross biological membranes. Using this technique we have previously shown that a membrane permeable version of profilin I (PTD4-profilin) increased aqueous humour outflow facility. Here we have investigated if a topical application of PTD4-profilin was able to modify intraocular pressure in rabbits. 10 μM PTD4-profilin (10 μL), reduced intraocular pressure by 20% compared to the control vehicle, this value being in the range of other commercial drugs, which produced intraocular pressure reductions between 18 and 35%. The mean-time effect for PTD4-profilin was 6.8 h and was also in the same range as commercial products that provided values between 4.3 and 5.5 h. According to the results presented here we propose PTD4-profilin as a new approach for the treatment of ocular hypertension and PTD4 as a new strategy to facilitate the penetration of molecules into the eye. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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