Increased levels of platelet-derived microparticles in patients with diabetic retinopathy
| Autor: | Shosaku Nomura, Masahito Imaizumi, Miwa Arichi, Akira Shozu, Nahoko Ogata, Masato Matsuoka, Miyo Matsumura |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Platelet Membrane Glycoproteins Endocrinology Coagulation cascade Antigens CD Internal medicine Diabetes mellitus Internal Medicine medicine Humans Platelet In patient Particle Size Aged Aged 80 and over Glycated Hemoglobin Diabetic Retinopathy CD63 business.industry Tetraspanin 30 General Medicine Diabetic retinopathy Middle Aged medicine.disease Surgery Endothelial stem cell P-Selectin Cholesterol Coagulation Case-Control Studies Disease Progression Female business |
| Zdroj: | Diabetes research and clinical practice. 68(3) |
| ISSN: | 0168-8227 |
| Popis: | Diabetic retinopathy is caused by capillary occlusions. Platelet-derived microparticles (PMPs) stimulate the coagulation cascade and increase leukocyte and endothelial cell adhesions, both of which are key events in the development of diabetic retinopathy. However, the correlation between the levels of PMPs and diabetic retinopathy has not been precisely determined. The PMPs levels and the expression of platelet CD62P and CD63 were measured in 92 diabetic patients. The level of PMPs was significantly correlated with the expression of CD62P (r = 0.76, P0.0001) and CD63 (r = 0.71, P0.0001). The mean level of PMPs in diabetics (507+/-15/10(4) platelets (plt), mean+/-S.E.) was significantly higher than that in normal. The PMPs levels increased with the progression of the diabetic retinopathy; 480+/-28/10(4) plt in diabetic patients without retinopathy (n = 25), 504+/-40/10(4) plt with mild or moderate non-proliferative diabetic retinopathy (n = 13), 512+/-29/10(4) plt with severe non-proliferative diabetic retinopathy (n = 25), and 528+/-25/10(4) plt with proliferative diabetic retinopathy (n=29). The PMPs level in patients with non-perfused retinal areas (582+/-27/10(4) plt, n = 24) was significantly higher than patients without non-perfused areas (469+/-23/10(4) plt, n = 30; P = 0.0096) and without diabetic retinopathy (P = 0.024). These high correlations indicate that increased levels of PMPs may accelerate diabetic retinopathy. |
| Databáze: | OpenAIRE |
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