The protective effects of chronic intermittent hypobaric hypoxia pretreatment against collagen-induced arthritis in rats
| Autor: | Hui Jie Ma, Fang Cui, Ming Cheng, Fang Yuan, Yi Zhang, Shu Xia Song, De Pei Li, Min Shi, Ai Jing Liu |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
Allergy medicine.medical_specialty animal structures Clinical Biochemistry T lymphocytes Arthritis HIF-1α macromolecular substances Pharmacology NF-κB chemistry.chemical_compound Internal medicine medicine Rheumatoid arthritis skin and connective tissue diseases Th1/Th2 business.industry Research Cell Biology medicine.disease musculoskeletal system Molecular medicine Rheumatology chemistry Immunology Rat Hypobaric hypoxia business Chronic intermittent hypobaric hypoxia Collagen-induced arthritis |
| Zdroj: | Journal of Inflammation (London, England) |
| ISSN: | 1476-9255 |
| Popis: | Objective To explore the immunological mechanisms underlying the effect of chronic intermittent hypobaric hypoxia (CIHH) pretreatment on collagen-induced arthritis (CIA) in rat. Methods Fifty-four adult male Sprague–Dawley rats were used in the experiment. Arthritis in CIA rats (n=18) was induced by injection of collagen. The CIHH+CIA rats (n=18) were treated with CIHH (simulated 3000 m altitude, 5 hours per day for 28 days, PO2=108.8 mmHg) before CIA. The control rats (n=18) were not given any treatment. Results (1) Incidence rate of CIA in CIHH+CIA rats was significantly lower than that in CIA rats (P |
| Databáze: | OpenAIRE |
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