BODIPY and 2,3-Dihydrophthalazine-1,4-Dione Conjugates As Heavy Atom-Free Chemiluminogenic Photosensitizers
| Autor: | Fatih Algi, Ömer Sonkaya, Aysun Degirmenci, Tugce Karaduman, Caner Soylukan |
|---|---|
| Přispěvatelé: | Sabire Yazıcı Fen Edebiyat Fakültesi |
| Rok vydání: | 2021 |
| Předmět: |
Heavy-atom Free Photosensitizer
Boron Compounds Chemiluminescence Photosensitizing Agents Singlet Oxygen Chemistry Photodynamic therapy (PDT) Porphobilinogen Biochemistry (medical) Biomedical Engineering Atom (order theory) General Chemistry Photochemistry Biomaterials chemistry.chemical_compound Photochemotherapy BODIPY CRET Luminol Boron Conjugate |
| Zdroj: | ACS Applied Bio Materials. 4:5090-5098 |
| ISSN: | 2576-6422 |
| DOI: | 10.1021/acsabm.1c00328 |
| Popis: | We disclose an interesting concept for developing heavy atom-free chemiluminogenic photosensitizers. To accomplish this, conjugates 2 and 3, which are composed of boron-dipyrromethene (BODIPY) and 2,3-dihydrophthalazine-1,4-dione units, are investigated. 2 and 3 are compared in terms of their photophysical properties, chemiluminescence responses, and singlet oxygen production. Strikingly, the results indicate that decoration of BODIPY with the 2,3-dihydrophthalazine-1,4-dione scaffold boosts the singlet oxygen generation. Furthermore, treatment of epidermoid laryngeal carcinoma Hep-2 (Hep-2) cells with conjugates 2 and 3 results in efficient cellular internalization which ensures live- cell imaging of Hep-2 cells. Finally, it is noteworthy that in vitro cytotoxicity assays reveal that both 2 and 3 induce cytotoxicity when illuminated with red light. Thus, 2 and 3 represent heavy atom-free chemiluminogenic photosensitizers. |
| Databáze: | OpenAIRE |
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