Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors
| Autor: | Alexey Vanichkin, Nir Osherov, Aviv Gazit, Abraham Novogrodsky, Alexander Levitzki, Miriam Patya |
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| Rok vydání: | 1994 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide Cell Survival Enzyme-Linked Immunosorbent Assay Pharmacology Biology Protein Serine-Threonine Kinases Nitric Oxide Benzylidene Compounds Nitric oxide Cell Line chemistry.chemical_compound Mice Nitriles Animals Phosphorylation Mitogen-Activated Protein Kinase 1 Multidisciplinary Dose-Response Relationship Drug Tumor Necrosis Factor-alpha Tyrosine phosphorylation Macrophage Activation Protein-Tyrosine Kinases Tyrphostins Mice Inbred C57BL Biochemistry chemistry Toxicity Macrophages Peritoneal Tumor necrosis factor alpha Biological Assay Female Bacterial outer membrane Tyrosine kinase |
| Zdroj: | Science (New York, N.Y.). 264(5163) |
| ISSN: | 0036-8075 |
| Popis: | Septic shock results from excessive stimulation of the host immune system, especially macrophages, by lipopolysaccharide (LPS), or endotoxin, which resides on the outer membrane of bacteria. Protein tyrosine kinase inhibitors of the tyrphostin AG 126 family protect mice against LPS-induced lethal toxicity. The protection correlates with the ability of these agents to block LPS-induced production of tumor necrosis factor alpha (TNF-alpha) and nitric oxide in macrophages as well as LPS-induced production of TNF-alpha in vivo. Furthermore, this inhibitory effect correlated with the potency of AG 126 to block LPS-induced tyrosine phosphorylation of a p42MAPK protein substrate in the murine macrophage. |
| Databáze: | OpenAIRE |
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