Effect of a 1-week, eucaloric, moderately high-fat diet on peripheral insulin sensitivity in healthy premenopausal women
| Autor: | Natalia M Branis, Jeanine Albu, Ryan W. Walker, Evan S. Berk, Marjan Etesami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism media_common.quotation_subject medicine.medical_treatment 030209 endocrinology & metabolism Overweight 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Follicular phase medicine Euglycemic Clamp Menstrual cycle Dietary Fat 030304 developmental biology media_common 2. Zero hunger 0303 health sciences business.industry Insulin medicine.disease Crossover study African American(s) Peripheral Endocrinology Metabolism medicine.symptom Insulin Resistance business |
| Zdroj: | BMJ Open Diabetes Research & Care |
| ISSN: | 2052-4897 |
| Popis: | Objectives To determine whether a weight-maintaining, moderate (50%) high-fat diet is deleterious to insulin sensitivity in healthy premenopausal women. Design/setting/participants 23 African-American and non-Hispanic white, healthy, overweight, and obese premenopausal women recruited in New York City, USA, fed either a eucaloric, 1-week long high-fat (50% of total Kcal from fat) diet or a eucaloric, 1-week long low-fat (30% of total Kcal from fat) diet, assigned in a randomized crossover design. Main outcome measures Peripheral insulin sensitivity and metabolic flexibility during a euglycemic hyperinsulinemic (80 mU/m2/min) clamp measured during the follicular phase of the menstrual cycle, at the end of each diet period. Results Peripheral insulin sensitivity (mg kg/fat-free mass/min (µU/mL)×10−1) was not decreased after the high-fat diet vs the low-fat diet (0.09±0.01 vs 0.08±0.01, p=0.09, respectively) in the combined group of African-American and white women, with no significant diet by race interaction (p=0.6). Metabolic flexibility (change in substrate utilization, ΔNPRQ, in response to insulin during the clamp) was similarly unaltered by the diet (0.12±0.01 vs 0.11, p=0.48, for the high-fat diet vs the low-fat diet, respectively) in the combined group of women, with no significant diet by race interaction (p=0.9). African–American women had a lower insulin clearance compared with the white women, regardless of the diet (p Conclusions We conclude that a short term (1 week), moderate (50%), eucaloric high-fat diet does not lower peripheral insulin sensitivity in healthy, overweight and obese premenopausal women. |
| Databáze: | OpenAIRE |
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