Oxaziridines as Possible Intermediates in Flavin Monooxygenases
| Autor: | H. W. Orf, David Dolphin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1974 |
| Předmět: |
Multidisciplinary
Chemical Phenomena Azirines Oxide Electron Spin Resonance Spectroscopy Flavin group Monooxygenase Hydroxylation Oxaziridine Peroxide chemistry.chemical_compound Chemistry chemistry Models Chemical Physical Sciences: Chemistry Flavins Oxygenases Organic chemistry Oxidation-Reduction |
| Popis: | The enzymatic hydroxylation reactions of flavin monooxygenases are suggested to involve an oxaziridine as the active oxygenating agent. The chemistry of these monooxygenases and their nonenzymatic model systems are consistent with an oxaziridine intermediate. Several advantages of the oxaziridine model over the previously proposed “carbonyl oxide” and flavin peroxide models are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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