The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis

Autor: Ulrich Spengler, Thomas Berg, Benjamin Krämer, Frank Lammert, Jacob Nattermann, Tobias Müller, Hans Dieter Nischalke, Christian Körner, Cordula Berger, Carolin Luda, Frank Grünhage, Tilman Sauerbruch, Natascha Vidovic, Johannes Oldenburg, Martin Coenen
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Lifestyle Causes of Cancer
Liver Cirrhosis
Male
Alcoholic liver disease
Cirrhosis
Gastroenterology and hepatology
Gastroenterology
Hepatitis
Liver Cirrhosis
Alcoholic
Risk Factors
Aged
80 and over
education.field_of_study
Multidisciplinary
Cancer Risk Factors
Liver Neoplasms
Hepatitis C
Middle Aged
Infectious hepatitis
Oncology
Nutritional Correlates of Cancer
Hepatocellular carcinoma
Infectious diseases
Medicine
Female
Liver cancer
Research Article
Adult
medicine.medical_specialty
Carcinoma
Hepatocellular
Genotype
Science
Genetic Causes of Cancer
Population
Viral and Bacterial Causes of Cancer
Viral diseases
White People
Young Adult
Internal medicine
Gastrointestinal Tumors
Genetics
medicine
Humans
Genetic Predisposition to Disease
education
Biology
Liver diseases
Aged
Evolutionary Biology
Population Biology
business.industry
Computational Biology
Cancers and Neoplasms
Membrane Proteins
Hepatocellular Carcinoma
Lipase
medicine.disease
digestive system diseases
Case-Control Studies
Genetic Polymorphism
Steatohepatitis
business
Population Genetics
Zdroj: PLoS ONE, Vol 6, Iss 11, p e27087 (2011)
PLoS ONE
ISSN: 1932-6203
Popis: BackgroundAn isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular carcinoma (HCC).MethodsWe compared distributions of PNPLA3 genotypes in 80 and 81 Caucasian patients with alcoholic and hepatitis C virus (HCV)-associated HCC to 80 and 81 age- and sex-matched patients with alcohol-related and HCV-related cirrhosis without HCC, respectively. PNPLA3 genotypes in 190 healthy individuals from the same population served as reference. Potential confounders obesity, diabetes, HCV genotype and HBV co-infection were controlled by univariate and multivariate logistic regression with forward variable selection.ResultsPNPLA3 genotypes were in Hardy-Weinberg equilibrium for all study groups. The frequency of the 148M allele was significantly (pConclusionThe PNPLA3 148M variant is a prominent risk factor for HCC in patients with alcoholic cirrhosis, while its effects are negligible in patients with cirrhosis due to HCV. This polymorphism provides an useful tool to identify individuals with particularly high HCC risk in patients with alcoholic liver disease that should be taken into account in future HCC prevention studies.
Databáze: OpenAIRE
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