Conjunctival Involvement in Paraneoplastic Pemphigus
| Autor: | Stephanie J. Meyers, Gary A. Varley, Arden H. Wander, Charles Camisa, David M. Meisler |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Pathology Lymphoma B-Cell Conjunctiva Paraneoplastic Syndromes Mucocutaneous zone Fluorescent Antibody Technique Conjunctival Diseases Autoimmune Diseases immune system diseases Humans Medicine skin and connective tissue diseases Aged Autoimmune disease integumentary system business.industry Pemphigus vulgaris Autoantibody Complement C3 Middle Aged medicine.disease Dermatology Ophthalmology Pemphigus Paraneoplastic pemphigus medicine.anatomical_structure Immunoglobulin G Female sense organs Bullous pemphigoid business |
| Zdroj: | American Journal of Ophthalmology. 114:621-624 |
| ISSN: | 0002-9394 |
| Popis: | Paraneoplastic pemphigus is a recently described autoimmune inflammatory mucocutaneous disease associated with an underlying neoplasm. Although histopathologic and direct immunofluorescence findings of involved skin and mucous membranes are consistent with pemphigus vulgaris, indirect immunofluorescence and immunoprecipitation study results are unique. We treated two patients with non-Hodgkin's lymphoma and paraneoplastic pemphigus. Both patients had bilateral bulbar conjunctival hyperemia and diffuse papillary tarsal conjunctival reactions. One patient had sloughing of conjunctival epithelium and the other had tarsal conjunctival cicatrization and forniceal shortening. Histopathologic findings of conjunctivae obtained from both patients were consistent with pemphigus vulgaris. Diffuse deposition of IgG and C3 in the intercellular substance of the conjunctival epithelium was demonstrated by direct immunofluorescence. Indirect immunofluorescence testing disclosed binding of autoantibodies to rodent bladder and intestinal epithelium. Immunoprecipitation disclosed antibodies reactive to Desmoplakin I (250 kd), bullous pemphigoid (230 kd), Desmoplakin II (210 kd) and 190-kd proteins. Ophthalmologists and pathologists should be aware of the conjunctival changes in paraneoplastic pemphigus. |
| Databáze: | OpenAIRE |
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