Impact of radiation dose and pre-treatment pain levels on survival in dogs undergoing radiotherapy with or without chemotherapy for presumed extremity osteosarcoma
| Autor: | Michael W. Nolan, Elizabeth M DiVito, Noah A Green, Siobhan Haney, B. Duncan X. Lascelles |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Survival 040301 veterinary sciences medicine.medical_treatment Pain Antineoplastic Agents Bone Neoplasms Radiation Dosage Radiosurgery 0403 veterinary science 03 medical and health sciences Fractures Bone 0302 clinical medicine Dogs medicine North Carolina Animals Dog Diseases Retrospective Studies Chemotherapy Univariate analysis Osteosarcoma General Veterinary Radiotherapy business.industry Medical record Hazard ratio Retrospective cohort study 04 agricultural and veterinary sciences medicine.disease Radiation therapy 030220 oncology & carcinogenesis Female Radiology business |
| Zdroj: | Veterinary and comparative oncologyREFERENCES. 18(4) |
| ISSN: | 1476-5829 |
| Popis: | The purpose of this bi-institutional retrospective study was to determine whether survival for dogs with extremity osteosarcoma (OS) is improved through the use of stereotactic radiotherapy (SRT; a single fraction of 25 Gy, or 36 Gy total given in three consecutive daily fractions) plus chemotherapy, vs lower dose conventionally planned and delivered hypofractionated radiotherapy (CHRT; 14-20 Gy total in 1-2 consecutive daily fractions) plus chemotherapy. We also sought to determine whether baseline pain severity influences oncologic outcomes following radiotherapy for canine extremity OS. The medical records of 82 dogs undergoing radiotherapy for confirmed or presumed OS were reviewed. In dogs receiving combinations of both chemotherapy and radiotherapy, survival was significantly longer with SRT vs CHRT (median overall survival time: 350 vs 147 days; P = .031). In a univariate analysis, dogs with pulmonary metastases and high pain at the time of irradiation had short overall survival times; use of high radiation doses and chemotherapy were associated with improved survival. Separate multivariable models were built to assess the predictive nature of various factors that might influence event-free or overall survival in dogs treated with radiotherapy, with or without chemotherapy; for dogs treated with both chemotherapy and radiotherapy, overall survival times were significantly longer when baseline pain scores were 'low' (vs 'high'; hazard ratio: 0.258; P = .030), radiation doses were high (hazard ratio: 0.943; P = .034). Neither pain nor radiation dose were associated with survival in dogs treated with radiotherapy, without chemotherapy. |
| Databáze: | OpenAIRE |
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