Red blood cell phosphatidylserine exposure is responsible for increased erythrocyte adhesion to endothelium in central retinal vein occlusion
| Autor: | Julien Picot, Emmanuel Héron, Olivier Hermine, M.-P. Wautier, J.-L. Wautier, Yves Colin |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Erythrocyte Aggregation Male medicine.medical_specialty Erythrocytes Endothelium Retinal Artery Occlusion Retinal Artery Phosphatidylserines Hematocrit Biology Erythrocyte aggregation Central retinal vein occlusion Internal medicine Retinal Vein Occlusion Cell Adhesion medicine Humans Annexin A5 Cell adhesion Aged medicine.diagnostic_test Cell adhesion molecule Retinal Vessels hemic and immune systems Hematology Middle Aged medicine.disease Red blood cell Endocrinology medicine.anatomical_structure Immunology Female |
| Zdroj: | Journal of Thrombosis and Haemostasis. 9:1049-1055 |
| ISSN: | 1538-7836 |
| DOI: | 10.1111/j.1538-7836.2011.04251.x |
| Popis: | Summary. Background: Retinal vein occlusion (RVO) is a common cause of permanent loss of vision. The pathophysiology is uncertain, although enhanced erythrocyte aggregation and blood hyperviscosity have been observed. Increased red blood cell (RBC) adhesion has been associated with vascular complications in several diseases, such as sickle cell anemia, diabetes mellitus or polycythemia vera. Objectives: To measure RBC adhesion to endothelial cells in RVO and to explore the molecular basis of the adhesion process. Patients and methods: We assessed RBC adhesion to endothelial cells and adhesion molecule expression among 32 patients with RVO. Patients with disease known to alter RBC adhesion were excluded (n = 8), and further investigation was conducted in 20 patients with central retinal vein occlusion (CRVO) and four patients with retinal artery occlusion (RAO), compared with 25 normal subjects. Results: Under static conditions, adhesion of CRVO RBC was increased (135 ± 7 × 102 mm−2) compared with RAO RBC (63 ± 5 × 102 mm−2) (P |
| Databáze: | OpenAIRE |
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